Research Article Open Access

The Glia Connection of the Glutamate/Glutamine Shuttle

Angelina Rodriguez1 and Arturo Ortega2
  • 1 Centro Universitario, Mexico
  • 2 Cinvestav-IPN, Mexico


Problem statement: Glia cells outnumber neurons but their role in synaptic transmission is still matter of debate. The recycling of Glutamate, the main excitatory neurotransmitter, carried out by the glutamate/glutamine shuttle, requires the involvement of glia, suggesting their involvement in neurotransmission. Approach: This review focuses on novel functions of glia proteins involved in this cycle. Results: An activity-dependent interaction of glial glutamate transporters, the Na+/K+ ATPase, the glutamine and glucose transporters might support glutamatergic neurotransmission. Conclusion: Glia cells that surround glutamatergic contacts, respond to synaptic activity and modify accordingly, the amount and function of the proteins involved in their interaction with neurons thus assuring a synaptic transmission.

Neuroscience International
Volume 3 No. 1, 2012, 32-38


Submitted On: 3 June 2012 Published On: 3 September 2012

How to Cite: Rodriguez, A. & Ortega, A. (2012). The Glia Connection of the Glutamate/Glutamine Shuttle. Neuroscience International, 3(1), 32-38.

  • 1 Citations



  • Glia cells
  • glutamate/glutamine shuttle
  • glutamate transporters
  • glutamine transporters
  • glia/neuronal coupling