TY  - JOUR
AU  - Rodriguez, Angelina 
AU  - Ortega, Arturo 
PY  - 2012
TI  - The Glia Connection of the Glutamate/Glutamine Shuttle
JF  - Neuroscience International
VL  - 3
IS  - 1
DO  - 10.3844/amjnsp.2012.32.38
UR  - https://thescipub.com/abstract/amjnsp.2012.32.38
AB  - Problem statement: Glia cells outnumber neurons but their role in synaptic transmission is still matter of debate. The recycling of Glutamate, the main excitatory neurotransmitter, carried out by the glutamate/glutamine shuttle, requires the involvement of glia, suggesting their involvement in neurotransmission. Approach: This review focuses on novel functions of glia proteins involved in this cycle. Results: An activity-dependent interaction of glial glutamate transporters, the Na+/K+ ATPase, the glutamine and glucose transporters might support glutamatergic neurotransmission. Conclusion: Glia cells that surround glutamatergic contacts, respond to synaptic activity and modify accordingly, the amount and function of the proteins involved in their interaction with neurons thus assuring a synaptic transmission.