@article {10.3844/amjnsp.2012.32.38,
article_type = {journal},
title = {The Glia Connection of the Glutamate/Glutamine Shuttle},
author = {Rodriguez, Angelina and Ortega, Arturo},
volume = {3},
year = {2012},
month = {Sep},
pages = {32-38},
doi = {10.3844/amjnsp.2012.32.38},
url = {https://thescipub.com/abstract/amjnsp.2012.32.38},
abstract = {Problem statement: Glia cells outnumber neurons but their role in synaptic transmission is still matter of debate. The recycling of Glutamate, the main excitatory neurotransmitter, carried out by the glutamate/glutamine shuttle, requires the involvement of glia, suggesting their involvement in neurotransmission. Approach: This review focuses on novel functions of glia proteins involved in this cycle. Results: An activity-dependent interaction of glial glutamate transporters, the Na+/K+ ATPase, the glutamine and glucose transporters might support glutamatergic neurotransmission. Conclusion: Glia cells that surround glutamatergic contacts, respond to synaptic activity and modify accordingly, the amount and function of the proteins involved in their interaction with neurons thus assuring a synaptic transmission.},
journal = {Neuroscience International},
publisher = {Science Publications}
}