Literature Review Open Access

Unveiling the Complex Relationship between Polycystic Ovary Syndrome and Cardiovascular Risk Factors: A Comprehensive Review

Anastasia Vladimirovna Poznyak1, Victoria Alexandrovna Khotina2,3, Vasily Nikolaevich Sukhorukov2,3, Tatiana Ivanovna Kovyanova1,2, Irina Alexandrovna Starodubtseva4, Natalia V. Elizova2, Alexey Viktorovich Churov2,5 and Alexander Nikolaevich Orekhov2,3
  • 1 Institute for Atherosclerosis Research, Moscow, Russia
  • 2 Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
  • 3 Petrovsky National Research Centre of Surgery, Moscow, Russia
  • 4 Department of Polyclinic Therapy, NN Burdenko Voronezh State Medical University, 10 Studencheskaya Street, Voronezh, Russia
  • 5 Institute on Aging Research, Russian Gerontology Clinical Research Centre, Pirogov Russian National Research Medical University, 16, 1st Leonova Street, Moscow, Russia

Abstract

Polycystic ovary syndrome remains a relatively unexplored endocrine disorder with significant implications for female health. Despite its prevalence and known associations with various metabolic disorders, the specific link between polycystic ovary syndrome and cardiovascular risk factors, particularly atherosclerosis, remains inadequately understood. This review aims to address the existing research gap by investigating the connection between polycystic ovary syndrome and cardiovascular risk factors. The objectives include examining the predisposition to atherosclerosis in females with polycystic ovary syndrome, assessing the impact of associated conditions like diabetes, dyslipidemia and obesity on cardiovascular health and highlighting the need for further investigation to clarify conflicting evidence in this area. This comprehensive review aims to provide insights into the complex interplay between polycystic ovary syndrome and cardiovascular and cardiometabolic risk factors, emphasizing the necessity for detailed studies to enhance understanding of this widespread condition.

OnLine Journal of Biological Sciences
Volume 25 No. 1, 2025, 10-21

DOI: https://doi.org/10.3844/ojbsci.2025.10.21

Submitted On: 12 March 2024 Published On: 2 October 2024

How to Cite: Poznyak, A. V., Khotina, V. A., Sukhorukov, V. N., Kovyanova, T. I., Starodubtseva, I. A., Elizova, N. V., Churov, A. V. & Orekhov, A. N. (2025). Unveiling the Complex Relationship between Polycystic Ovary Syndrome and Cardiovascular Risk Factors: A Comprehensive Review. OnLine Journal of Biological Sciences, 25(1), 10-21. https://doi.org/10.3844/ojbsci.2025.10.21

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Keywords

  • Atherosclerosis
  • Cardiovascular Disease
  • Ovaries
  • PCOS