Circulating Immune Complexes as an Important Link between Inflammation and Lipid Alterations in Atherosclerosis

Abstract

This review article rigorously investigates the emerging facets of atherosclerosis pathogenesis through an exhaustive examination of the existing data on the intricate interplay between lipid metabolism disorders and inflammation. A primary objective of this study is to thoroughly explore the role of Circulating Immune Complexes (CIC) as a pivotal indicator of this multifaceted interaction. The focus of this review centers on the presence of autoantibodies to LDL in the bloodstream and their unequivocal association with atherosclerotic lesions in both patient populations and experimental animal models. Hypothesizing that the modification of lipoproteins incites an immune response resulting in the generation of LDL antibodies, a meticulous experimental design was employed. This entailed meticulous collection and analysis of extensive datasets encompassing LDL-CIC and their intricate relationship with LDL modifications. While ethical considerations were not explicitly discussed in this study, we affirm the indispensability of ethical research practices and urge future investigations to explicitly address these vital aspects. Furthermore, we acknowledge our obligation to clearly articulate the research's contribution to the field. As such, this study imparts invaluable insights into the intricate mechanisms underpinning the progression of atherosclerosis. Notably, it underscores the profound significance of LDL modifications and circulating immune complexes in elucidating the intricate nature of this pernicious disease. In conclusion, this rigorous review article substantiates novel aspects of atherosclerosis pathogenesis, reinforcing the paramount importance of lipid metabolism disorders and inflammation. By elucidating the involvement of circulating immune complexes and their intricate correlations with LDL modifications, this study significantly advances the existing knowledge in the field. The findings presented herein expand our understanding of atherosclerosis and lay a robust foundation for further research endeavors and potential therapeutic interventions.