Review Article Open Access

VLDL in Atherosclerosis: Variety of Mechanistic Implications

Anastasia Vladimirovna Poznyak1, Victor Yurievich Glanz2, Vasily Nikolaevich Sukhorukov2, Alexandra Alexandrovna Melnichenko2, Victoria Alexandrovna Khotina2, Arthur Anatolievich Lee2,3, Dmitry Felixovich Beloyartsev4 and Alexander Nikolaevich Orekhov2
  • 1 Institute for Atherosclerosis Research, Moscow, Russia, Russia
  • 2 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
  • 3 Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, Russia
  • 4 Vascular Surgery Department, A. V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia

Abstract

Very-Low-Density Lipoprotein (VLDL) particles play a pivotal role as precursors for Intermediate-Density Lipoprotein (IDL) and eventually transform into Low-Density Lipoprotein (LDL). These particles have been categorized based on size and particle charge. Various types of VLDL impact diverse physiological processes in the human body. The accumulation of VLDL, along with other triglyceride-rich lipoproteins, significantly contributes to the development of atherosclerotic lesions, plaque rupture, progression of liver disorders such as hepatitis and Non-Alcoholic Fatty Liver Disease (NAFLD) and other conditions including obesity, insulin resistance and coronary artery disease. This review delves into the potential of VLDL in averting atherosclerosis and seeks to identify its therapeutic applications. Special emphasis is placed on exploring the role of VLDL in atherosclerosis, understanding its atherogenic properties and utilizing VLDL as a predictive marker for pathological conditions. The study design focuses on examining the data on pathways through which VLDL could be leveraged as a therapeutic target and preventive measure against cardiovascular diseases.

OnLine Journal of Biological Sciences
Volume 24 No. 4, 2024, 777-787

DOI: https://doi.org/10.3844/ojbsci.2024.777.787

Submitted On: 25 November 2023 Published On: 29 July 2024

How to Cite: Poznyak, A. V., Glanz, V. Y., Sukhorukov, V. N., Melnichenko, A. A., Khotina, V. A., Lee, A. A., Beloyartsev, D. F. & Orekhov, A. N. (2024). VLDL in Atherosclerosis: Variety of Mechanistic Implications. OnLine Journal of Biological Sciences, 24(4), 777-787. https://doi.org/10.3844/ojbsci.2024.777.787

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Keywords

  • Lipids
  • Atherosclerosis
  • Cardiovascular Disease
  • Lipid Metabolism
  • VLDL