Literature Review Open Access

Atherosclerosis as Age-Related Disease: The Potential of Sirtuins Treatment

Anastasia Vladimirovna Poznyak1, Victor Yurievich Glanz2, Vasily Nikolaevich Sukhorukov3, Alexandra Alexandrovna Melnichenko3, Elizaveta Mikhailovna Pleshko4, Alexander Leonidovich Golovyuk5 and Alexander Nikolaevich Orekhov1
  • 1 R&D Laboratory, Institute for Atherosclerosis Research, Moscow, Russia
  • 2 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
  • 3 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
  • 4 Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia
  • 5 Department of Vascular Surgery, A. V. Vishnevsky National Medical Research Center of Surgery, 27 Bolshaya Serpukhovskaya Street, 117997 Moscow, Russia

Abstract

Atherosclerosis, a global health concern, has attracted researchers worldwide due to its severe consequences. The elderly are particularly susceptible to cardiovascular diseases and events, making them a high-risk group. Although gaps in our understanding of atherosclerosis pathogenesis persist, it is evident that oxidative stress, endothelial dysfunction, inflammation, mitochondrial dysfunction, and autophagy impairments are key components of its development. Remarkably, these features are also observed in the aging process, suggesting that atherosclerosis may be an aging-associated disease. However, causality relationships between aging, atherosclerosis, and associated mechanisms continue to be speculative. Additionally, the lack of effective therapeutic options for both atherosclerosis and aging poses a significant challenge. Sirtuins hold promise as potential agents in addressing this challenge. This review aims to consolidate evidence on the association between atherosclerosis and vascular aging through mitochondrial dysfunction and discusses the potential role of sirtuins as therapeutic options for atherosclerosis.

OnLine Journal of Biological Sciences
Volume 24 No. 4, 2024, 503-514

DOI: https://doi.org/10.3844/ojbsci.2024.503.514

Submitted On: 12 November 2023 Published On: 16 May 2024

How to Cite: Poznyak, A. V., Glanz, V. Y., Sukhorukov, V. N., Melnichenko, A. A., Pleshko, E. M., Golovyuk, A. L. & Orekhov, A. N. (2024). Atherosclerosis as Age-Related Disease: The Potential of Sirtuins Treatment. OnLine Journal of Biological Sciences, 24(4), 503-514. https://doi.org/10.3844/ojbsci.2024.503.514

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Keywords

  • Atherosclerosis
  • Cardiovascular Disease
  • Sirtuins
  • Aging
  • CVD