Research Article Open Access

A MIXTURE DROPOUT MECHANISM IN A LONGITUDINAL STUDY WITH TWO TIME POINTS: A METHADONE STUDY

Zohreh Toghrayee1, Parvin Jalili2, Heng Chin Low1 and Ardavan Taghva2
  • 1 Universiti Sains Malaysia, Malaysia
  • 2 , Iran

Abstract

One of the most important issues that confront statisticians in longitudinal studies is dropouts. A variety of reasons may lead to withdrawal from a study and produce two different missingness mechanisms, namely, missing at random and non-ignorable dropouts. Nevertheless, none of these mechanisms is tenable in most studies. In addition, it may be that not all of dropouts are nonignorable. Many dropout handling methods have been employed by assuming only one of these dropout mechanisms. In this study, the dropout indicator is improved to take into account both dropout mechanisms. In this two-stage approach, a selection model is combined with an imputation method for dropout process in a longitudinal study with two time points. Simulation studies in a variety of situations are conducted to evaluate this approach in estimating the mean of the response variable at the second time point. This parameter is estimated by using maximum likelihood method. The results of the simulation studies indicate the superiority of the proposed method to the existing ones in estimating the mean of the variable with dropouts. In addition, this method is performed on a methadone dataset of 161 patients admitted to an Iranian clinic to estimate the final methadone dose.

Journal of Mathematics and Statistics
Volume 10 No. 3, 2014, 293-303

DOI: https://doi.org/10.3844/jmssp.2014.293.303

Submitted On: 10 March 2014 Published On: 26 April 2014

How to Cite: Toghrayee, Z., Jalili, P., Low, H. C. & Taghva, A. (2014). A MIXTURE DROPOUT MECHANISM IN A LONGITUDINAL STUDY WITH TWO TIME POINTS: A METHADONE STUDY. Journal of Mathematics and Statistics, 10(3), 293-303. https://doi.org/10.3844/jmssp.2014.293.303

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Keywords

  • Longitudinal Data
  • Dropout Mechanism
  • Imputation Method
  • Ignorability
  • Non-Ignorability