Research Article Open Access

Assessment of Quality of Life, Anxiety and Depression in Children with Turner Syndrome: A Case-Control Study

Khaled Saad1, Abdulrahman Abdullah Al-Atram2, Khaled A. Abdel Baseer3, Ahmed M. Ali1 and Amira A. El-Houfey1
  • 1 Assiut University, Egypt
  • 2 Almajmaah University, Saudi Arabia
  • 3 South Valley University, Egypt

Abstract

Turner syndrome is a genetic disorder that affects only females and is caused by the loss of the whole or a part of the X-chromosome. The aim of this study was to assess the quality of life and frequency of anxiety and depression in a cohort of Egyptian children with Turner Syndrome (TS) diagnosed in Assiut university hospitals, Assiut, Egypt. In a case-control study; 40 females with Turner Syndrome (TS), aged 6-16 years, diagnosed in Assiut university hospitals, Upper Egypt, were compared to 40 age- matched apparent healthy girls as controls. They were subjected to full history taking, thorough clinical examination and assessment of pediatric quality of life; we used pediatric anxiety and depression scores. For cognitive assessment, Health-Related Quality of Life (HR-QOL) and psychological evaluation of anxiety and depression; we used the “Children Depression Scale” (CDI), “Children Anxiety Scale” Wechsler Intelligence Scale for Children (WISC) and SF-36 by trained psychiatrists blind to the study. Our study revealed Children Anxiety Scale scores ranged from 13-41 for patients with TS and 5-23 for controls. The mean anxiety scores were significantly higher in TS patients as compared to controls (p<0.001), (27.32±7.1 versus 15.2±2.9). In addition, we found CDI scores ranged from 38-70 for patients and 31-56 for controls. Mean depression scores were significantly higher in TS patients as compared to controls (p<0.001), (54.7±8.8 versus 36.8±9.9). The physical and mental component summary scores of HR-QOL were lower in TS patients when compared to controls. We concluded that female children with TS experience significant problems with HR-QOL, anxiety and depression, which need thorough psychiatric evaluation and rapid intervention of these patients.

Neuroscience International
Volume 6 No. 1, 2015, 8-12

DOI: https://doi.org/10.3844/amjnsp.2015.8.12

Submitted On: 25 January 2015 Published On: 13 March 2015

How to Cite: Saad, K., Al-Atram, A. A., Abdel Baseer, K. A., Ali, A. M. & El-Houfey, A. A. (2015). Assessment of Quality of Life, Anxiety and Depression in Children with Turner Syndrome: A Case-Control Study. Neuroscience International, 6(1), 8-12. https://doi.org/10.3844/amjnsp.2015.8.12

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Keywords

  • Turner Syndrome
  • Anxiety
  • Depression