Research Article Open Access

What Is The “Safest” Non-Steroidal Anti-Inflammatory Drugs?

Patompong Ungprasert1, Wonngarm Kittanamongkolchai1, Chrystal Price1, Supawat Ratanapo1, Napat Leeaphorn1, Daych Chongnarungsin1 and Wisit Cheungpasitporn1
  • 1 Bassett Medical Center and Columbia University, United States


Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) which are widely used in clinical practice are also very well-known for their various adverse reactions. Each NSAID has its own unique safety profile and selecting an appropriate NSAID must be individualized for each patient based on his or her medical needs and risk factors. We reviewed literatures on NSAIDs, focusing on their adverse reaction profile. We reviewed and compared the incidence of adverse reaction from individual NSAIDs according to organ systems. This review includes both selective COX-2 inhibitors and non-selective NSAIDs. Based on the most up-to-date evidence, ibuprofen appears to be the preferred NSAIDs based on its favorable GI and nephrotoxicity profiles. Naproxen might be considered in patients who have greater cardiac risk. Celecoxib, at the dose of less than or equal to 200 mg day-1, might be an option in the patients who are at high risk for GI bleeding.

Current Research in Medicine
Volume 3 No. 2, 2012, 115-123


Submitted On: 29 May 2012 Published On: 18 June 2012

How to Cite: Ungprasert, P., Kittanamongkolchai, W., Price, C., Ratanapo, S., Leeaphorn, N., Chongnarungsin, D. & Cheungpasitporn, W. (2012). What Is The “Safest” Non-Steroidal Anti-Inflammatory Drugs?. Current Research in Medicine, 3(2), 115-123.

  • 16 Citations



  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
  • COX-2 inhibitor
  • adverse drug reaction
  • adverse reactions
  • safety profile
  • clinical practice
  • organ systems