Research Article Open Access

Tacrolimus Dosing Challenges in an African American Child

Teresa V. Lewis1, Tracy M. Hagemann1 and Martin A. Turman1
  • 1 University of Oklahoma Health Sciences Center, United States

Abstract

It has been suggested that African Americans have decreased effectiveness with immunosuppressive drugs. Data regarding the pharmacokinetics of tacrolimus in African Americans are limited. We present the case of an African American child in whom management of nephrotic syndrome caused by focal segmental glomerulosclerosis has been challenging due to unpredictable patient specific pharmacokinetic disposition of tacrolimus. Racial differences have been documented in literature to have an important impact on the pharmacokinetics and pharmacodynamics of certain drugs. As a result, African American patients may require larger doses or more frequent administration of certain medications to achieve therapeutic efficacy compared to Caucasians and other ethnic groups.

American Journal of Pharmacology and Toxicology
Volume 1 No. 3, 2006, 36-39

DOI: https://doi.org/10.3844/ajptsp.2006.36.39

Submitted On: 16 December 2006 Published On: 30 September 2007

How to Cite: Lewis, T. V., Hagemann, T. M. & Turman, M. A. (2006). Tacrolimus Dosing Challenges in an African American Child. American Journal of Pharmacology and Toxicology, 1(3), 36-39. https://doi.org/10.3844/ajptsp.2006.36.39

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Keywords

  • African American
  • FK506
  • pharmacokinetics
  • tacrolimus