Research Article Open Access

Crosstalk between Oxidative Stress Signaling and HER2 Pathway in Breast Cancer

Vanessa Jacob Victorino1, Adriano Martin Felis Aranome2, Fernanda Carolina de Campos2, Ana Cristina da Silva do Amaral Herrera2, Rubens Cecchini2 and Carolina Panis2
  • 1 University of São Paulo, Brazil
  • 2 State University of Londrina, Brazil


About 20% of breast cancer patients overexpress the Human Epidermal growth factor Receptor-2 (HER2), also known as ErbB2. HER2-overexpression is associated with enhanced tumor malignancy and its overexpression is related to specific target therapy against breast tumors and other cancers. HER2-mediated pathways in tumor cells act on behalf of the tumor conferring aggressive characteristics. Several reports demonstrated the occurrence of toxicity during the anti-HER2 therapy and this fact has been associated with the generation of reactive species and oxidative stress. However, the link between HER2 and oxidative stress signaling is still poorly understood. The aim of this review is to point out the interplay between oxidative stress and HER2 signaling in breast cancer. An overview regarding HER2 biology and oxidative stress pathways is provided with a special focus in studies that implicate on HER2-generation of reactive species and oxidative stress during trastuzumab-based treatments.

American Journal of Immunology
Volume 10 No. 4, 2014, 176-182


Submitted On: 5 February 2014 Published On: 17 January 2015

How to Cite: Victorino, V. J., Aranome, A. M. F., Campos, F. C. D., Herrera, A. C. D. S. D. A., Cecchini, R. & Panis, C. (2014). Crosstalk between Oxidative Stress Signaling and HER2 Pathway in Breast Cancer. American Journal of Immunology, 10(4), 176-182.

  • 2 Citations



  • HER2
  • Breast Cancer
  • Oxidative Stress
  • Therapy