Research Article Open Access

Transforming Growth Factor-β: An Indirect Inducer of Th17 Cell Differentiation both in Human and Murine System

J. Schumann1
  • 1 University of Leipzig, Germany

Abstract

Since their first description only some years ago Th17 cells have become of vital importance in immunological research. However, the role of TGF-β in Th17 cell development is still a matter of controversial discussion. Predicted to have a key function in Th17 cell differentiation in the mouse TGF-β was shown to inhibit IL-17 production of human CD4+ T cells. Moreover, recent data indicate TGF-β signaling in T cells to be dispensable for Th17 cell differentiation in the murine system. Hence, rather being a specie-specific factor TGF-β is likely to act as an indirect inducer of Th17 cell differentiation both in mice and men.

American Journal of Immunology
Volume 6 No. 2, 2010, 20-24

DOI: https://doi.org/10.3844/ajisp.2010.20.24

Submitted On: 24 August 2010 Published On: 30 June 2010

How to Cite: Schumann, J. (2010). Transforming Growth Factor-β: An Indirect Inducer of Th17 Cell Differentiation both in Human and Murine System. American Journal of Immunology, 6(2), 20-24. https://doi.org/10.3844/ajisp.2010.20.24

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Keywords

  • Transforming growth factor
  • T helper cell
  • mice and men
  • murine system