Research Article Open Access

Ciprofloxacin Does Not Exert Nephrotoxicity in Rats

Asli Baykal1, Figen Sarigül1, G Süleymanlar1, Paula I. Moreira2, George Perry3, Mark A. Smith4 and Yakup Alicigüzel1
  • 1 Akdeniz University Medical School, United States
  • 2 University of Coimbra, Portugal
  • 3 Case Western Reserve University, United States
  • 4 University of Texas at San Antonio, United States

Abstract

Ciprofloxacin, a member of the fluoroquinolone class, is an antibiotic used as a treatment for infections including the Anthrax bacteria. Studies concerning the safety and efficacy of ciprofloxacin have been controversial with respect to nephrotoxicity. Using rats orally treated with ciprofloxacin (400mg/kg/d), the effects of this drug were analyzed measuring several indications of nephrotoxicity: β-NAG, creatinine, blood urea nitrogen, and sodium and potassium levels in blood samples. Additionally, histological analyses were performed. β-NAG values, a measure of early renal damage, were significantly increased after 4 and 7 days of treatment (p = 0.001 and p = 0.004, respectively) compared with control rats. However, 7 days post-treatment, β-NAG values decreased to control levels indicative that adaptive responses were induced to prevent nephrotoxicity. These results indicate that ciprofloxacin in doses comparable to those commonly prescribed does not induce nephrotoxicity. Altogether, they further support the idea that ciprofloxacin can be safely used.

American Journal of Infectious Diseases
Volume 1 No. 3, 2005, 145-148

DOI: https://doi.org/10.3844/ajidsp.2005.145.148

Submitted On: 25 March 2005 Published On: 30 September 2005

How to Cite: Baykal, A., Sarigül, F., Süleymanlar, G., Moreira, P. I., Perry, G., Smith, M. A. & Alicigüzel, Y. (2005). Ciprofloxacin Does Not Exert Nephrotoxicity in Rats. American Journal of Infectious Diseases, 1(3), 145-148. https://doi.org/10.3844/ajidsp.2005.145.148

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Keywords

  • Antibiotics
  • nephrotoxicity
  • rats