Research Article Open Access

Diagnostic Potential of Inflammatory Biomarker Levels in the Serum of Patients with Hepatitis B Infection: A Retrospective Study

Hyeokjun Yun1, Bo Kyeung Jung2, In Soo Rheem2, Kap No Lee 3 and Jae Kyung Kim4
  • 1 Department of Medical Laser, Dankook University Graduate School of Medicine, Republic of Korea
  • 2 Department of Laboratory Medicine, Dankook University College of Medicine, Republic of Korea
  • 3 Department of Diagnostic Academy, Bioneer Corporation, Daejeon, Republic of Korea
  • 4 Department of Biomedical Laboratory Science, College of Health and Welfare, Dankook University, Republic of Korea

Abstract

This study aimed to evaluate the diagnostic biomarker potential of C-Reactive Protein (CRP) and Procalcitonin (PCT) levels in the serum of individuals infected with the Hepatitis B Virus (HBV). The patients were divided into two age groups: Younger (<60 years) and older (≥60 years). An Electrochemiluminescence Immunoassay (ECLIA) platform was employed for the serological analysis to quantify the biomarker levels. A retrospective analysis was conducted on a cohort of HBV-infected patients and serum samples were collected from 200 individuals infected with HBV as well as from healthy controls. ECLIA revealed significantly increased levels of the pro-inflammatory markers CRP and PCT in both younger and older HBV-infected patients compared with those for participants in the healthy controls (p<0.0001). Importantly, the serum CRP and PCT levels were independent of age and sex. These findings provide evidence for increased serum CRP and PCT levels following HBV infection, indicating a potential correlation between these biomarkers and HBV infection. Thus, this study demonstrates the promising clinical diagnostic significance of CRP and PCT in HBV infections when assessed using ECLIA.

American Journal of Biochemistry and Biotechnology
Volume 19 No. 3, 2023, 217-226

DOI: https://doi.org/10.3844/ajbbsp.2023.217.226

Submitted On: 18 May 2023 Published On: 10 August 2023

How to Cite: Yun, H., Jung, B. K., Rheem, I. S., Lee , K. N. & Kim, J. K. (2023). Diagnostic Potential of Inflammatory Biomarker Levels in the Serum of Patients with Hepatitis B Infection: A Retrospective Study. American Journal of Biochemistry and Biotechnology, 19(3), 217-226. https://doi.org/10.3844/ajbbsp.2023.217.226

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Keywords

  • C-Reactive Protein
  • Hepatitis B Viru
  • Procalcitonin
  • Serological Assay