@article {10.3844/crdsp.2021.62.70, article_type = {journal}, title = {The Anti-Nociceptive/Anti-Inflammatory Actions of Botulinum Toxin A for the Treatment of Chronic Pain: A Literature Review}, author = {Hajj, Racha and Haddad, Camille}, volume = {12}, year = {2021}, month = {Aug}, pages = {62-70}, doi = {10.3844/crdsp.2021.62.70}, url = {https://thescipub.com/abstract/crdsp.2021.62.70}, abstract = {The aim of this article is to describe the new actions of botulinum toxin A for chronic pain treatment. BT/A inhibits the exocytosis of synaptic vesicles containing the pain mediators neurotransmitters, reduces the post traumatic trigeminal neuralgia pain, inhibits the release of microglia derived TNF-α as well as other pro inflammatory cytokines, viable treatment option in the case of patients who do not respond to conservative treatment methods of chronic pain (medication) BT/A is an emerging treatment for chronic pain; patients with severe chronic facial pain, not responding to conventional treatments, can respond to botulinum type a injections}, journal = {Current Research in Dentistry}, publisher = {Science Publications} }