TY  - JOUR
AU  - Schebesch, Karl-Michael 
AU  - Hochreiter, Elisabeth Bruendl Andreas 
AU  - Scheitzach, Judith 
AU  - Herbst, Sylvia Bele Andreas 
AU  - Brawanski, Alexander 
AU  - Proescholdt, Martin 
AU  - Lohmeier, Anette 
AU  - Stoerr, Eva-Maria 
AU  - Schoedel, Petra 
PY  - 2014
TI  - CALCITONIN GENE-RELATED PEPTIDE IN SERUM AFTER SPONTANEOUS SUBARACHNOID HEMORRHAGE
JF  - Neuroscience International
VL  - 5
IS  - 1
DO  - 10.3844/amjnsp.2014.10.17
UR  - https://thescipub.com/abstract/amjnsp.2014.10.17
AB  - Endogenous Calcitonin Gene-Related Peptide (CGRP) stored in perivascular nerve fibers around the cerebral arteries mediates vasodilation and regulates cerebral blood flow under physiological conditions. Increased levels of CGRP have been continually reported in patients with migraine, but the role of CGRP in the pathophysiology of Subarachnoid Hemorrhage (SAH) has not yet been sufficiently evaluated. Over 10 days, serum was prospectively collected from 33 consecutive patients (17 women, 16 men; mean age 52.8 years) with spontaneous non-traumatic SAH. All patients were graded III or IV according to the Fisher Score. CGRP levels were determined by means of an Enzyme-Immunosorbent Assay (EIA). CGRP concentrations were correlated to (1) the anatomical localization of the aneurysm (anterior circulation or posterior circulation), (2) the treatment modality (clipped group, coiled group, or untreated group) and (3) the rate of ischemia determined by computed tomography (ischemia group, non-ischemia group, or iatrogenic ischemia group). (1) Anatomical localization: CGRP levels were significantly higher in patients with a ruptured aneurysm of the anterior circulation (p