@article {10.3844/ajbbsp.2022.68.77,
article_type = {journal},
title = {Evaluation of Mir 29c-3p and Mir 31-5p Serum Values in Predicting Nephropathy in Type 2 Diabetic Patients},
author = {Habieb, Mona S. and Elhelbawy, Nesreen Gamal and Elzorkany, Khaled M. and Nooh, Mohamed Z. and Elhelbawy, Mohammad G. and Khader, Heba F.},
volume = {18},
number = {1},
year = {2022},
month = {Feb},
pages = {68-77},
doi = {10.3844/ajbbsp.2022.68.77},
url = {https://thescipub.com/abstract/ajbbsp.2022.68.77},
abstract = {Diabetic Nephropathy (DN) is a prime complication of diabetes with various pathological mechanisms. microRNAs (miRNAs) have emerged as an important factor in the pathogenesis of renal disorders. We aimed to analyze serum miR 29c-3p and miR 31-5p in diabetic patients in relation to albuminuria and eGFR. Also, the correlations between these miRNAs and cystatin C were assessed. This study was conducted on 180 Type 2 Diabetes Mellitus (T2DM) patients and 60 age and gender matched controls. The patients were divided into three groups: Normoalbuminuric (Group I), microalbuminuric (Group II) and macroalbuminuric (Group III). miRNA expression analysis was assessed via real-time PCR. The diabetic patients showed decreased miR 29c-3p and miR 31-5p serum values and increased cystatin C compared with the controls. miR31-5p had better sensitivity (92.31%), specificity (93.62%) and AUC (0.958) than miR 29c-3p (69.23% sensitivity, 85.11% specificity and AUC = 0.785) in the prediction of an eGFR },
journal = {American Journal of Biochemistry and Biotechnology},
publisher = {Science Publications}
}