@article {10.3844/ajbbsp.2008.408.415,
article_type = {journal},
title = {Investigations in the molecular events of Transitional Cell Carcinoma of the Bladder},
author = {Kadhim, H.S. and Abdulamir, A.S. and Hafidh, R.R. and Abubaker, F. and Abbas, K.A.},
volume = {4},
number = {4},
year = {2008},
month = {Dec},
pages = {408-415},
doi = {10.3844/ajbbsp.2008.408.415},
url = {https://thescipub.com/abstract/ajbbsp.2008.408.415},
abstract = {Problem Statement: Transitional Cell Carcinoma (TCC) of the bladder 
is a significant health problem worldwide. The molecular mechanisms of tumor development 
and progression are complicated but likely involve the interaction of tumor suppressor 
genes, oncogenes, cell cycle regulatory proteins and other factors. Hence this 
study tries to explore the role of p53, bcl-2, c-myc and Ki-67 in TCC of the bladder 
in correlation with different clinicopathological criteria which are tumor grade, 
muscle invasion by the tumor and disease presentation, primary or recurrent tumor. 
Approach: Thirty patients with TCC of the bladder were involved 
in the period from March 2007 - May 2008. Tumors were diagnosed by histopathology 
and compared with 20 control subjects. The expressions of p53, bcl-2, c-myc and 
Ki-67 proteins were investigated by immunohistochemistry (IHC). Results: 
Increased expression of p53 and bcl-2 was associated with tumor grade 
and muscle invasion (p0.05). 
C-myc expression was only associated with muscle invasion (p},
journal = {American Journal of Biochemistry and Biotechnology},
publisher = {Science Publications}
}