@article {10.3844/ajbbsp.2005.54.63,
article_type = {journal},
title = {PDX-1 and MafA: Key Transcription Factors in Pancreas},
author = {Kaneto, Hideaki and Miyatsuka, Takeshi and Nakatani, Yoshihisa and Matsuoka, Taka-aki},
volume = {1},
number = {2},
year = {2005},
month = {Jun},
pages = {54-63},
doi = {10.3844/ajbbsp.2005.54.63},
url = {https://thescipub.com/abstract/ajbbsp.2005.54.63},
abstract = {Pancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development, β-cell differentiation and in maintaining normal β-cell function by regulating several β-cell-related genes including insulin. PDX-1 has potency to induce insulin-producing cells in non β-cells in various tissues such as pancreas and liver and PDX-1-VP16 fusion protein more efficiently induces insulin-producing cells, especially in the presence of NeuroD or Ngn3. MafA is a recently isolated β-cell-specific transcription factor and functions as a potent transactivator for the insulin gene. MafA markedly enhances insulin gene promoter activity and ameliorates glucose tolerance in diabetic mice, especially in the presence of PDX-1 and NeuroD. Taken together, PDX-1 and MafA play a crucial role in inducing insulin-producing cells and could be a therapeutic target for diabetes.},
journal = {American Journal of Biochemistry and Biotechnology},
publisher = {Science Publications}
}