@article {10.3844/ajavsp.2021.202.211, article_type = {journal}, title = {Isoquinoline Alkaloids and the Ionophore Monensin Supplemented Alone or Combined on Ruminal Fermentation and Nutrient Digestibility in Steers Fed a High-Energy Diet}, author = {Urías-Estrada, Jesús D. and Castro-Pérez, Beatriz I. and Estrada-Angulo, Alfredo and Gaxiola-Camacho, Soila and Ponce-Barraza, Elizama and Barreras, Alberto and Corona, Luis and Zinn, Richard A. and Martínez-Álvarez, Iván G. and Soto-Alcalá, Jorge and Plascencia, Alejandro}, volume = {16}, number = {3}, year = {2021}, month = {Oct}, pages = {202-211}, doi = {10.3844/ajavsp.2021.202.211}, url = {https://thescipub.com/abstract/ajavsp.2021.202.211}, abstract = {The aim of this experiment was to investigate the Influence of Alkaloids (IQA) and sodium Monensin (MON) supplementation on characteristics of ruminal fermentation, microbial protein synthesis and site and extend of digestion. For this, 4 cannulated steers were used in a 4×4 Latin square design. Treatments consisted of a high-energy basal diet supplemented with: (1) No additive (Control), (2) 15 mg IQA/ kg DM, (3) 30 mg MON/kg DM and (4) combination of IQA+MON. There were no treatment effects (P> 0.10) on ruminal and total tract digestion of OM, NDF and starch. Supplemental IQA increased (P 0.20) when IQA was combined with MON. Supplemental MON decreased (P0.43) on ruminal pH. There were no MON effects, or synergism (P≥0.23), on ruminal pH and ruminal VFA proportions. Supplemental IQA increased (P≤0.05) ruminal acetate and tended (P = 0.06) to increase acetate: Propionate ratio. Compared with control, MON did not affect (P>0.10) VFA proportions. Ruminal protozoa and total bacterial counts were decreased by both, IQA and MON when offered separately. Plasma liver enzymes were not affected by treatments. The enhancement in N utilization by steers receiving IQA supplementation can be attributed to reduced ruminal N degradation and by increased microbial N flow to the small intestine. There were no additive effects of the combination of IQA plus MON on measures of digestion. }, journal = {American Journal of Animal and Veterinary Sciences}, publisher = {Science Publications} }