TY  - JOUR
AU  - Abdullah, Faez Firdaus Jesse 
AU  - Naji, Odhah Mohd 
AU  - Lila, Mohd Azmi Mohd 
AU  - Saad, Mohd Zamri 
AU  - Haron, Abd Wahid 
AU  - Hambali, Idris Umar 
AU  - Mahmood, Zaid Khudher 
PY  - 2017
TI  - Pro-Inflammatory Cytokine (IL-1β and IL-6) Response in Goats Challenged with Corynebacterium pseudotuberculosis and its Immunogen Mycolic Acids
JF  - American Journal of Animal and Veterinary Sciences
VL  - 12
IS  - 1
DO  - 10.3844/ajavsp.2017.26.31
UR  - https://thescipub.com/abstract/ajavsp.2017.26.31
AB  - The causative agent of Caseous Lymphadenitis (CLA) is Corynebacterium pseudotuberculosis. A chronic disease of sheep and goats which is mainly characterized by suppurative abscesses in both superficial and visceral lymph nodes. There is paucity of information on the proinflammatory cytokine (IL-1β and IL-6) responses due to C. pseudotuberculosis and Mycolic Acid (MAs) inoculation in goats. Therefore, this study was conducted to evaluate the immunogenicity of C. pseudotuberculosis and MAs. Twelve clinically healthy crossbred Boer female goats were divided into 3 groups; A, B and C with 4 goats per group. The A group was injected with 2 mL sterile Phosphate Buffered Saline (PBS) intradermally as negative control group while B group was inoculated with 2 mL of MAs extract intradermally. Group C was inoculated with 2 mL 1×109 colony forming unit (cfu) of live C. pseudotuberculosis intradermally. Blood was collected from the jugular vein periodically for IL-1β and IL-6 analysis throughout the experimental period. The results showed significant increase (p